Smash Up: Monster Smash can be played on its own as a two-player game or combined with other Smash Up titles to allow for up to four players to compete at the same time.
- Vampires gain power as they destroy your opponents' minions
- Mad Scientists have released death in the form of powerful creations and can empower various minions
- Werewolves have explosive power to beat down opponents
- Giant Ants work as a great hive mind, spreading their power around as necessary to ensure their atomic-age victory